الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Chronic wound remain one of the most common and serious consequences of diabetes. Wound healing may be delayed due to abnormal cell function, hyperglycemia, peripheral neuropathy, peripheral vascular disease, sus¬ceptibility to infections and abnormal planter foot pres¬sures. Delayed wound healing causes prolong morbid¬ity and may ultimately end up in loss of part or whole of the foot.
Animal and observational studies have shown that statins are beneficial in promoting the rate of wound healing and wound strength. Simvastatin has been found to enhance vascular endothelial growth factor (VEGF) production and improve wound healing in an experimental model of diabetes.
The aim of the work was directed to prepare simvastatin topical formulations to be applied on chronic wounds and to evaluate their healing effects. In addition, this work aimed at applying the prepared formulations on chronic wound model to show the effectiveness of simvastatin topical formulations as wound healing promoter.
In chapter one, the prepared simvastatin preparations was inspected visually and their pH was determined. In addition, the in-vitro drug release from these preparations was evaluated and found to be dependent on the rheological properties of these preparations.
In chapter two, the healing effect of simvastatin gel formulations was evaluated and compared to that of phenytoin 2% aerosol using diabetic rats as animal model.
The result showed that SIM gel formulations were effective as phenytoin 2% aerosol in fast and higher contraction rate of wound in diabetic albino rats and complete wound healing observed on day 9 post surgery for SIM anhydrous group and commercial phenytoin aerosol group which characterized by complete epithelization and hair follicle formation .
In chapter three, the effectiveness of simvastatin topical preparation was evaluated and compared to that of phenytoin 2% aerosol. Thirty five patients with chronic wounds were participated in the study.
The obtained results showed enhanced chronic wound healing with topical simvastatin 1 % gel when compared with other commercial wound healing agent phenytoin 2% aerosol. In conclusion: topical simvastatin gel is an inexpensive medication which may improve wound healing but should be used in conjunction with standard management for contaminated or dirty wounds.