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العنوان
Serum vitamin D and Recurrent Benign Paroxysmal Positional Vertigo /
المؤلف
Abdel Hamid, Alaa Abdel Hamid Awad.
هيئة الاعداد
باحث / الاء عبدالحميد عوض عبدالحميد
مشرف / طارق محمد الدسوقي
مشرف / ايمان مصطفى بسيوني
مشرف / رحاب محمد عبدالكريم
الموضوع
Vertigo. Vitamin D.
تاريخ النشر
2020.
عدد الصفحات
119 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب
الناشر
تاريخ الإجازة
2/6/2020
مكان الإجازة
جامعة بني سويف - كلية الطب - امراض السمع والصمم والاتزان
الفهرس
Only 14 pages are availabe for public view

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from 129

Abstract

Vertigo is defined as the subjective perception of rotation or translation without external movement. Its estimated lifetime prevalence is between 3 and 10% of the population (Murdin and Schilder, 2015).
BPPV is a vestibular end-organ disorder, characterized by a transitory spinning sensation typically lasting less than a minute that is precipitated by positional changes of the head with respect to gravity. A wide spectrum of symptom severity exists, ranging from mild dizziness to vertiginous episodes, severe enough to cause nausea and vomiting, and significantly impair daily functioning. The disorder is prone to spontaneous remissions and recurrences.
Vitamin D is mostly synthesized in the skin and is changed into 25‐hydroxyvitamin D in the liver and into 1,25‐dihydroxyvitamin D in the kidney to act on various parts of the human body (Buki et al., 2013). Among metabolites, 25‐hydroxyvitamin D has the highest serum concentration, and the concentration level is a good indicator of the vitamin D held in vivo (Rhim, 2014).
The aim of this study was to measure the serum levels of 25-hydroxyvitamin D3 (25-OH D3) and calcium total & ionized in patients with BPPV and determine if there is a difference in the serum levels of vitamin D3 between patients with and without recurrence.
This study included 15 patients with Recurrent BPPV and 15 patients with Non Recurrent BPPV
All groups were subjected to Medical history taking , otological examination ,Videonystagmography. Then , Serum levels of vitamin D and calcium were measured after the diagnosis of BPPV.
Results revealed that:
1- Mean age of patients was 47.97 years with standard deviation of 10.34. There was no statistically significant difference in gender between both study groups.
2- There was non-significant difference between both groups regarding the affected canal (posterior, lateral or multiple canals) (p value > 0.05).
3- There was non-significant difference between recurrence and non-recurrence groups as regards unilateral or bilateral affection.
4- Expression of vitamin D in non-recurrence group I ranged from 10.5 to 33.5, with mean value of (24.93 ± 6.89). While in recurrence group II, it ranged from 5.5 to 32.1, with mean value of (21.34 ± 7.82). The expression of vitamin D was non-significant between the two groups, with p value <0.05.
5- There was no statistically significant difference (p = 0.89) in vitamin D expression between patients with non-recurrence group I and recurrence group II.
6- The expression of calcium in non-recurrence group I ranged from 10.5 to 33.5, with mean value of (24.93 ± 6.89). While in recurrence group II, it ranged from 5.5 to 32.1, with mean value of (21.34 ± 7.82). The expression of calcium was non-significant between the two groups, with p value <0.05.
7- All the patients in the two groups were in the normal level 100% of the total Calcium level.
8- The expression of Ionized Calcium in non-recurrence group I showed non-significant difference from its counterpart in recurrence group II (p value <0.05).
9- There was no statistically significant difference (p = 1) in Ionized Calcium expression between patients with non-recurrence group I and recurrence group II.