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Abstract The effect of addition different concentrations (2.5 and 5 %) as powder of cinnamon (Cinnamonum zeylanicum) and apple fruits (Malus pumila) and its mixture on biological, biochemical, histological and antiobesity changes of obese rats was evaluated. Forty eight male albino rats weighting 140 ±10 g were used in this study and divided into 8 groups, each group contain 6 rats. Rats were treated by high fat diet (20% animal fat) to induce obese. Results showed that the highest body weight gain and feed intake recorded for (5%) mixtures from apple fruits and cinnamon powder, while the lowest recorded for (2.5%) apple fruits powder with significant difference. The highest feed efficiency ratio of treated group recorded for (5%) cinnamon powder, while the lowest FER recorded for (2.5%) cinnamon powder with significant differences. The lowest AST, ALT value recorded for group fed on (5%) mixtures of cinnamon and apple fruits powder with significant difference. The lowest cholesterol and triglycerides levels recorded for group fed on (5%) mixtures of cinnamon and apple fruits powder. The highest (HDL-c) levels recorded for group fed on (5%) mixtures of cinnamon and apple fruits powder. While, the lowest (LDL-c) value recorded for group fed on (5%) mixtures of cinnamon and apple fruits powder with significant difference. The lowest (VLDL-c) value recorded for group fed on (5%) mixtures of cinnamon and apple fruits powder with significant difference. While, the lowest uric acid, urea and creatinine values recorded for group fed on (5%) mixtures of cinnamon and apple fruits powder with significant difference. As conclusion, obese rats treated with (5%) mixtures of cinnamon and apple fruits powder had improvement lipid profile, liver and kidney functions compared with cinnamon and apple fruits powder. |