الفهرس 
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Abstract
Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by thrombocytopenia that results from platelet autoantibodies, leading to an accelerated clearance of opsonized platelets by phagocytes. The etiology of ITP is still not clear, both genetic and environmental factors might play a role in the development of such disease. It has been reported that several gene polymorphisms influence host susceptibility to ITP.
SDF1 gene rs266085 is a genetic factor that influence the onset of several autoimmune diseases such as SLE, ITP and Rheumatoid arthritis.
The aim of this study was to investigate the association of single nucleotide polymorphism (SNP) in the gene of SDF1 RS 266085 with ITP in Egyptian children patients.
We have analyzed 60 cases with ITP (28 males and 32 females) together with 90 healthy controls from Beni -suef university Hospital, Health insurance hospital Beni -suef.
Our result demonstrated that there was statistical difference in the distribution SDF1 gene rs266085 (CC, CT and TT) between cases and controls. There was significantly higher frequency of CC genotype and C allele carriers in cases than controls as regard the codominent, dominent and over dominant models (p value<0.05) also there was significantly high frequency of CT genotype carriers in controls more than cases (p value<0.05) Furthermore, There was statistically significant association between CC genotype carriers and therapeutic response to steroid (steroid dependency), (p value< 0.05)but there was no other association between other genotype carriers and other lines of treatment , clinical picture or history data.
Also, no significant association was determined between various genotype carriers (CC, CT, TT) of SDF1 gene and the chronicity of the disease . This study concluded that there is association between SDF1 gene rs266085 and susceptibility to develop ITP in pediatric patient as well as steroid dependency.However, there was no significant relation between various genotype carriers and disease activity ( chronicity of the disease).