الفهرس 
Introduction
Tendon structureOnly 14 pages are availabe for public view
 |  | from | 136 |  |  |
| | | from | 136 | | |
Abstract
This experimental study aimed to investigate the role of silver nanoparticles and platelet rich fibrin on the healing of the severed superficial digital flexor tendon (SDFT) along different intervals.
This study was carried out on 27 clinically health adult donkeys. They were randomly divided into 3 groups, according to the type of treatment; each group had 9 donkeys.
Group1: Suture of severed SDFT without treatment (control group).
group 2: Suture ofsevered SDFT + platelet rich fibrin (PRF group)
group 3: Suture ofsevered SDFT + Silver nanoparticles(SNP Group).
Theconcentration of the silver nanoparticles was 157 µM (157 ppm) &The size was ~ 7.96 nm to 14.8 nm.
The animals in each group were divided into three equal subgroups, the first subgroup was examined after one month, the second subgroup was examined after two months and the third subgroup was examined after three months. All groups were examined at intervals one, two and three months.
Clinical examinations were performed to assure the normality of the tendons condition. All animals vaccinated from tetanus and dewormed before the operations. Fasting of the animals was also performed for 12 hours before the operation. General anaesthesia was performed using xylazine and ketamine for induction and the maintenance. The experimental operations were performed on the right forelimb in all groups of animals. Full thickness tenotomy was performed inSDFT. The double locking loop pattern was the used pattern and the No.0 nylon was the used suture material for the tenorrhaphy for all groups.
The operated right forelimbs of the animals in all groups were fixed after the operations. Post-operative care was achieved by injection of a broad spectrum antibiotic (Penicilline-Streptomycin) and anti-inflammatory (phenylbutazon) daily for five successive days. The animals rested in the stable for 2 weeks, post operatively. Then they were hand-walked for 10 minutes every day. The animals were evaluated by clinical, gross and histo-pathological examinations.
The result of the clinical examination of the animal, gross and microscopically examination of the healed tendon revealed good results in the SNP and PRF groups especially at the third month compared to the control group, however SNP is preferred as it has a potent anti-inflammatory and antibiotic effect.