الفهرس 
Neurobiology of PainOnly 14 pages are availabe for public view
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Abstract
It has never been easy to understand what the schizophrenic patient can or cannot feel. Due to the heterogenicity of schizophrenia symptoms, most papers have an obvious discrepancy regarding the nature and etiology of the altered pain perception in patients.
Pain perception can be classified into the sensory-discriminative pathway, which includes the quality, intensity, duration and location of pain and the motivational affective one, that includes emotional reactions leading to expression of pain.
And as pain is the most important pointer of disease, hence the importance to understand the unique pain phenomena associated with schizophrenia. So, this study aimed to understand this altered phenomena by conducting a case - control study, using electrical stimulation as a method to examine both the sensory pathway by detecting the nociceptive threshold, and the emotional – cognitive pathway by detecting the subjective pain threshold.
We selected 24 schizophrenia patients in a full remission based on clinical assessment and 12 healthy individuals comparable to the patients to participate in our study. In our patient group, we excluded any other mental disorders, any neurological disorders, any acute or chronic pain conditions and any patient taking pain medication 24 hour prior to our procedures.
Both our patient and our control groups after having their informed consent, were subjected to full medical and neurological examination. The patient group underwent assessment using the positive and negative symptom scale (PANSS) and the schizophrenia cognition rating scale (SCoRS) to assess the severity of symptoms.