الفهرس 
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Abstract
Breast cancer is a diverse group of diseases with different phenotypic and genotypic subtypes. This has significant therapeutic and prognostic effects with the molecular subtyping being an essential therapeutic requirement. Molecular subtyping depends on tumor markers’ expression status: ER/PR status, HER2neu overexpression, and Ki-67 index. This is usually done via immunohistochemistry (IHC) or Fluorescence in Situ Hybridization (FISH). IHC is an invasive, expensive and time-consuming test. IHC also suffers from false-positive tests with some authors requiring confirmation via FISH. FISH is technically more demanding, time-consuming and more expensive assay but is more consistent and more objective compared to IHC.
In our study we tried to predict the hormonal status, HER2neu status and molecular subtype via imaging. We examined the imaging features of 60 breast cancer patients via mammosonography and MRI and correlated those features with HR status, HER2neu status and molecular subtype
Here we showed that patient’s age, tumor size, margins, microcalcifications on mammography, posterior acoustic features on ultrasonography, enhancement pattern and kinetics on MRI strongly correlate with hormonal receptor status, HER2neu status and molecular subtype. Hormonal positive tumors tend to be of non-circumscribed margins with posterior acoustic shadowing on ultrasonography. HR negative tumors tend to be larger, more commonly associated with circumscribed margins and present with washout kinetics on MRI. HER2neu positive tumors tend to present microcalcifications. TNBC is usually circumscribed masses with washout kinetics on MRI.