الفهرس 
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Abstract
• Introduction Glaucoma causes optic neuropathy in a progressive that is characterized by is characterized by loss of retinal ganglion cells and their respective axons. In the evaluation of glaucoma, RNFL assessment is relevant, because thinning of the RNFL is correlated directly with loss of ganglion cells.A Swept-Source OCT Angiography device (SS-OCTA) provided images of optic disc, superficial and deep macular capillary plexuses microcirculation. uses longer wavelength (1050 nm) for imaging ,This provided an in depth imaging of the optic disc and macular capillary plexuses.Aim of the work:This is study aims to compare the macular changes in patients with primary open- angle glaucoma with control subjects by Swept Source optical coherence tomography angiography.Patients and methods:This is a comparative cross-sectional study.This study was conducted on 80 eyes of 80 subjects attending to Mansoura ophthalmic center the eyes were classified into:group one: 40 eyes with primary open-angle glaucoma.group two: 40 eyes healthy control subjects.•Results:The mean vessel density was statistically significantly lower in superficial & deep vascular plexuses in patients with POAG when compared with control, and showed that the Mean Vessel density (VD) of SVP & DVP values were significantly lower in severe glaucoma eyes followed by moderate & mild glaucoma and healthy eyes, with p value (p<0.001), In this study, the comparison between macular GC-IPL thickness and perpapillary RNFL thickness measurements had significantly lower in patients with different stages of glaucoma and controls.Conclusion Swept Source-OCTA is a new technology provides high-speed, non-invasive, depth-resolved imaging of the retinal vasculature using motion contrast. Significant decrease in vessel density of superficial and deep vascular plexuses was detected in POAG patients when compared to control group. Significant decrease in GCIPL thickness and Peripapillary RNFL was detected in POAG patients when compared to control group OCTA technology should be further studied to assess whether it provides an accurate non-invasive option for detailed visualization of the retinal microvasculature alterations in glaucoma.