الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis deals with synthesis of novel α-aminophosphonate derivatives bearing quinoline moiety starting from commercially available aldehyde, aminoquionlines and phosphites. The formation of the key 4-aminoquinolines 3 needed for this study was achieved by reaction of 4,7-dichloroquinoline 1 with commercially available aliphatic and aromatic diamines 2 in presence of base as shown in Scheme 1 The three one-pot synthesis of unexpected cyclic α-aminophosphonates bearing quinoline moiety was accomplished in good yields using 4- aminoquinolines 3, glutaraldehyde 4, diphenyl phosphite 5 dissolved in acetonitrile in presence of LiClO4 as a Lewis acid catalyst. |