الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Prostate cancer is one of the top five malignancies in the world and the most common in the United States (US) that is responsible for at least 10% of cancer deaths in adult men. In Egypt, although the incidence seems low relative to other countries, fatalities caused by prostate cancer are significantly higher. With the lack of survival benefit for strenuous screening and decreased awareness we tend to see a great proportion of new cases of localized prostate cancer diagnosed with higher risk who tend to present in advanced age and who usually suffer from other comorbid conditions.
In fact, Intermediate and high-risk prostate cancer should be actively treated if long life expectancy is calculated and many prefer a definitive course of radiotherapy rather than facing the complications of a major surgery. Besides, there exists an established role for the addition of androgen deprivation therapy (ADT) to radiotherapy, albeit the significant added toxicity.
Recently, many advances took place that facilitated accurate delivery of escalated curative doses to the prostate while sparing the surrounding organs at risk. Intensity modulated radiotherapy (IMRT) guided by adequate online imaging (IGRT) constitute one of these corner stone advances with favorable toxicity profile.
This study aimed to compare daily IGRT with IMRT with an old IMRT technique without daily imaging. The primary endpoint was comparing planning parameters and both acute and late radiotherapy induced toxicity, and the secondary endpoint was time to prostatic specific antigen (PSA) nadir and biochemical relapse free survival.