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العنوان
Nail Fold Capillaroscopy abnormality in Behcet’s Disease and Relation to Disease Activity among Egyptian Patients \
المؤلف
Hamada, Magdeldin Naghim Ibrahim.
هيئة الاعداد
باحث / مجد الدين ناغم ابراهيم حماده
مشرف / أمينة بدر الدين عبد العزيز
مشرف / نوران أسامة أحمد العزيزي
مشرف / شفيقة إبراهيم إبراهيم
تاريخ النشر
2019.
عدد الصفحات
143 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - الباطنة العامة
الفهرس
Only 14 pages are availabe for public view

from 143

from 143

Abstract

Behcet’s disease is an auto immune disease with multisystem affection, the most common manifestations are in the form of oral or genital ulcers, eye affection, recurrent thrombosis. The disease discovery is known in human literature since early times, despite this the disease is still unfamiliar by many physicians and many complications could occur before disease discovery, treatment is by immunosuppressive therapy which also had its implications on the long term, unfortunately it has no sure diagnostic tests and relies mainly on clinical criteria, there are few scores to assess its activity, (Behcet’s Disease Current Activity Form) BDCAF score is a reliable follow up tool with wide accreditation.
Nailfold Capillaroscopy is a technique to visualize capillaries in nailfold as capillaries run parallel in this area showing better morphology, it can correlate diseases with the shape of blood capillaries, there are many ongoing trials to use capillaroscopy for different diseases either for diagnosis or follow up.
In our study we used nail fold capillaroscopy in an attempt to be of diagnostic value in BD and also to correlate it with the disease activity using BDCAF score.
Patients were subjected to full medical history, full examination, basic lab tests as ESR, CRP, CBC, eye examination including fundus examination, nailfold capillaroscopy and assessment of disease activity using BDCAF score.
The most frequent clinical manifestations were oral ulcers, with 100% affected, followed by genital ulcers 84%, followed by eye affection 62%.
Patients had statistically significant affection of anterior and posterior chamber, but with no correlation to BDCAF score, posterior chamber affection was significantly correlated to capillary ramification and tortuosity.
Patients had higher total leucocytic count, higher ESR and lower hemoglobin levels, ESR was also significantly correlated with capillary dilation and tortuosity, CRP didn’t show statistically significant difference.
It was found that 70% of the patients had nailfold capillary changes, the most prevalent changes were tortuosity 64%, microhemorrhages 54%, and capillary dilation 24%, the disease activity wasn’t related to the capillary changes.
We conclude that Behcet’s disease causes nailfold capillaroscopic changes and that capillaroscopy can be used to complete the picture to diagnose Behcet’s disease and that further studies are required to see a more specific pattern.