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Abstract Ideal management of necrotic immature permanent teeth to close the blunderbuss apical opening still of challenge and debate. The current attempts are to restore teeth vitality for good sensation, function and esthetic.This study aimed to evaluate the platelet-rich fibrin for revascularization of necrotic immature permanent teeth. This study was of two parts; the first was histological which included 32 immature root canals from four young dogs divided equally into two main groups; contaminated and uncontaminated. Each group was divided into two subgroups treated either by platelet-rich fibrin (PRF) (experimental) or calcium hydroxide (control) for 6 months and evaluated histologically. The second part of this study was clinical that included 28 single rooted teeth of children selected from Pediatric Dentistry Clinic, Faculty of Dentistry, Mansoura University. The included teeth (root canals) were divided into two main groups (contaminated and uncontaminated). Each group was then divided into two subgroups according to treatment modality (PRF and calcium hydroxide). Teeth then followed at baseline (preoperatively) and after twelve months using cone beam computed tomography (CBCT) and by peri-apical radiography at baseline (preoperative) , 3 months, 6 months and 9 months. The evaluation was by measuring root length, diameter of apical foramen and radiographic root area (RRA) at each follow up period. |