الفهرس 
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Abstract
30 eyes from 30 diabetic patients with focal DME were enrolled in this comparative, prospective randomized study from October 2017 to October 2018. Patients were divided into two groups. group (1) included 15 eyes that received focal laser photocoagulation as needed and group (2) included 15 eyes that received topical bromfenac eye drops twice daily for 6 months. Patients were followed up for 6 months.
The aim of this study was to evaluate the safety and efficacy of topical bromfenac compared to focal laser photocoagulation in treatment of focal DME.
All included patients underwent BCVA assessments, anterior segment examinations using slit lamps, intraocular pressure evaluation using a Goldmann applanation tonometer and posterior segment examinations using slit lamp biomicroscopy with +90 and +78 diopters Volk lenses. Fundus fluorescein angiography (FFA) and optic coherence tomography (OCT Heidelberg Engineering) were implemented for all patients before treatment. Follow up by ophthalmic examination and OCT was employed after 1, 3 and 6 months of treatment.
In group (1), the mean age was 55.6 8.47 years (range, 41 - 68 years) while in group (2), the mean age was 57.1 6.06 years (range, 40 - 65 years). There were 10 (66.7%) men and 5 (33.3%) women in group (1) while there were 6 (40%) men and 9 (60%) women in group (2).
There was no statistically significant visual improvement in either group after 1, 3 or 6 months in comparison with baseline (P > 0.05).
After 6 months; in group (1), BCVA was improved in 26.7 % of patients, stabilized in 60 % and deteriorated in 13.3 % in comparison with baseline. While in group (2); 40 % showed improved BCVA, 53.3 % had no change regarding BCVA and 6.7% had deteriorated BCVA in comparison with baseline.
In comparison with baseline; in group (1), there was no significant CMT reduction after 1 month (P = 0.065) but there was statistically significant CMT reduction after 3 months (P = 0.016) and after 6 months (P < 0.001).
In group (2) there was significant CMT reduction after 1 month (P = 0.022), after 3 months (P = 0.003) and after 6 months (P < 0.001).
Two patients (13.3 %) in group (1) needed a second laser session which was performed 3 months after the first one. While no patient in group (2) needed rescue laser.