الفهرس 
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Abstract
S
pinal anesthesia has been shown to be an easy, rapid, and safe technique for cesarean section. Nevertheless, it has some side effects; most common among these side effects are Spinal anaesthesia induced hypotension (SAIH), intraoperative nausea and vomiting in more than 66% of patients and bradycardia are the most common side effects encountered with SA and are more pronounced in pregnant patients, the incidence being as high as 52.6% and 2.5% in normal patients. The occurrence of hypotension and bradycardia can be dangerous as it compromises placental circulation and can have a detrimental effect on the foetus.
Ondansetron, is a 5HT3 antagonist commonly used for the prevention of nausea and vomiting, has been safely used to blunt the Bezold–Jarisch reflex, resulting in less bradycardia and hypotension in parturient undergoing spinal anesthesia. Glucocorticoids are well known for their analgesic, anti-inflammatory, immune-modulating, and antiemetic effects has been used in this study to access their effect in blunting hypotensive response after SA through increasing responsiveness to endogenous catecholamines and decreasing need for ephedrine.
This study was conducted on 75 patients who underwent elective cesarean section under SA who matched the inclusion criteria and were randomly allocated into 3 groups each containing 25 patients. The first group received Ondansetron 8 mg, the second group received 8 mg Dexamethasone and the third group received 10 ml normal saline. Patients were evaluated regrding their hemodynamic parameters including Mean arterial blood pressure, heart rate, respiratory rate and peripheral oxygen saturation and were measured before and after induction and every5 minutes till the end of procedure
The result of our study showed that 8 mg ondansetron is more effective than 8 mg dexamethasone in the attenuation of post spinal hypotension and bradycardia. The study showed that there was statistically significant difference considering the heart rate, SBP, MAP, DBP in ondansetron than dexamethasone . Oxygen saturation,shivering and PDPH were insignificantly different in all groups. Also, that Dexamethasone 8 mg was as effective as ondansetron 8 mg in providing a simple and effective intra and postoperative nausea and vomiting prevention method.