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العنوان
Synthesis of Some New Heterocyclic Systems Containing Nitrogen with Expected Potential Biological Activity /
المؤلف
Samir,Sandy Samy.
هيئة الاعداد
باحث / Sandy Samy Samir
مشرف / Ahmed Said Ahmed Youssef
مشرف / Magdy Mohamed Hemdan Mohamed
مشرف / Wael S. I. Abou El-Magd
تاريخ النشر
2019
عدد الصفحات
384p.;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية العلوم - الكيميـــــــــــاء
الفهرس
Only 14 pages are availabe for public view

from 384

from 384

Abstract

Diazines and Triazines and their derivatives play an important role in medicinal chemistry due to their high biological activity. They are known to possess a broad spectrum of pharmacological activities such as antiviral, antibacterial, fungicidal, insecticidal, herbicides, hypotensive, hypothermic activities, in vitro supporting their anti-HIV, anticancer activities and biological inhibitors.
The original work of this thesis can be classified into three parts:
Part 1: In this part Synthesis of hydrazino 1,2,4-triazine derivative and its reactions with different reagents to form novel triazine derivatives.
Part 2: In this part Synthesis of an acid hydrazide derivative and its utility in building of new hetrocylic systems such as oxadiazole, triazole and pyrazole derivatives.
Part 3: The antitumor activities of some of the synthesized compounds were examined against liver and breast cancer cell lines.