الفهرس 
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Abstract
Schistosomiasis is one of the most of parasitic diseases which mostly affect the liver and intestine causing granuloma formation, fibrosis and certain necrotic changes in the hepatic tissues. It is a major source of morbidity affecting more than 207 million people in 76 countries.
Chemotherapy is the most effective tool for the control of schistosomiasis in case of the absence of available vaccine. There are many anti-schistosomal drugs available worldwide. Praziquantel is currently the drug of choice for the treatment of schistosomiasis because of its high efficacy against all schistosome species, relative safety, ease of administration, mild to moderate side effects and low cost.
The present study was carried out to investigate the effect of some natural products, methanolic extract of Ocimum basilicum, aqueous extract of Crocus sativus and/or praziquantel treatment on some parasitological, histological, immunological, biochemical parameters and scanning electron microscopy of adult worm as follow:
1- Parasitological parameters:
Worm burden
Oogram pattern in the liver and intestine
Ova count in the hepatic and intestinal tissue.
2- Histological parameters:
Measurement granuloma diameter
Histology of liver and intestine
Summery and Conclusion
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3- Immunological and biochemical parameters:
Total IgG
IL-10
Cell markers (CD4-CD8) using flow cytometry analysis
CD3-CD20 using Immunohistochemistry
SOD
CAT
4- Scanning electron microscopical examination of S. mansoni worms isolated from infected control group and different groups treated with PZQ, Ocimum basilicum, Crocus sativus or combination to detect the effect of the drugs on it.
In this study, seventy male albino mice were used and classified into 10 groups 7 mice/each as follow:
Experiment Ι
group 1: Normal mice were served as healthy control.
group 2: Mice infected with S. mansoni and sacrified after 8 weeks post infection were served as infected control.
group 3: mice were infected (6 weeks post infection) and treated with PZQ (300mg/kg) given orally for two consecutive days.
group 4: Mice were infected (6 weeks post infection) and treated with OBE (100 mg/kg) given orally and daily for two weeks.
group 5: Mice were infected (6 weeks post infection) and treated with combination of PZQ and OBE as previously described.
Experiment ΙΙ
group 1: