الفهرس 
Classification of Chicory
HISTOLOGICAL RESULTSOnly 14 pages are availabe for public view
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Abstract
The present work aimed to evaluate the effect of Chicory, Sonchus, Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as 5%) on paracetamol intoxicated and immunity of rats. For this purpose, the studies included about 40 rats about 150/100(g) weight. Rats were fed on normal (basal) diet. The animals were divided to 8 equal groups; one was kept as control- ve group, while the other 7 groups were treated orally by paracetamol (500 mg / kg.B.Wt.) for 5 days to induce hepatotoxicity.
group (2): Control positive (+ve), in which hepatotoxicity rats were given orally paracetamol then were fed on basal diet for 28 days.
group (3): Paracetamol hepatotoxicity rats were fed on basal diet containing 5 % Chicory for 28 days.
group (4): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Sonchus for 28 days.
group (5): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Egyptian leek for 28 days.
group (6): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Chinese leek for 28 days.
group (7): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Egyptian celery for 28 days.
group (8): Paracetamol hepatotoxicity rats were fed on basal diet containing 5% Chinese celery for 28 days.
At the end of experimental period (28 day), animals were scarified. Blood samples were collected to determine the following parameters: Antioxidant enzymes (SOD,CAT and GPx), level of serum liver enzymes (ALT,AST and ALP) and AST/ALT, serum total protein, serum albumin, serum globulin ,total bilirubin, direct bilirubin, indirect bilirubin ,Total cholesterol, triglycerides, lipoprotein fractions (HDL-c, LDL-c and VLDL-c), atherogenic index (AI), uric acid, urea nitrogen, creatinine. Complete blood count including immunity cells count (HGB, HCT, RBC, PLT, MCV, MCH, MCHC, WBC, Lymph, NEUTROPHILS, and MONO) were assessed. BWG calculated, liver, kidney, heart, lungs and spleen were weighted then livers and kidneys kept in (10%) formalin solution for histopathological examination.
The results could be summarized as follows:
1- Due to hepatointoxication, rats BWG, FI and FER were decreased.
2- Feeding on basal diet contained Chicory, Sonchus, Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as5%) raised the BWG, FI and FER.
3- Inflicting with paracetamol raised the internal organs weights while the reverse indicated on feeding with Chicory, Sonchus, Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as5%).
4- Paracetamol hepatotoxicity rats showed increased TC, TG, LDL, GLOB, T.BILI, DIR. bili, Indirect. bili & VLDL ,but decreased the serum HDL,TP,ALB.
5- Rats fed on Sonchus (group4) showed the best treatment for lowering TC.
6- The best serum (TG) was recorded for group5 (hepatic rats fed on Egyptian leek) when compared to control (+) group.
7- The best serum (HDL-c) was observed for group 5 (hepatic rats fed on Egyptian leek) when compared to control (+) group.
8- Rats fed on group 5(Egyptian leek) recorded the best treatment for lowering serum (LDL-c).
9- Paracetamol hepatotoxicity rats then fed on (group5) Egyptian leek recorded the best treatment for considering serum (VLDL-c).
10- Rats fed in group 5(Egyptian leek) recorded the best treatment for raising serum (TP).
11- Paracetamol hepatotoxicity rats then fed on (group5) Egyptian leek recorded the best treatment considering serum (albumin).
12- The best serum (globulin) was recorded for group 5 (hepatic rats fed on Egyptian leek) when compared to control (+) group.
13- Rats fed in group 5(Egyptian leek) recorded the best treatment for lowering serum (T.bili).
14- The best serum (dir.bili.) was recorded for group 5 (hepatic rats fed on Egyptian leek) when compared to control (+) group.
15- Paracetamol hepatotoxicity rats then fed in (group5) on Egyptian leek recorded the best treatment considering serum (indir.bili).
16- Inflicting rats with paracetamol hepatotoxicity raised the activities of serum GOT, GPT and ALP. When feeding with Chicory, Sonchus, Egyptian leek, Chinese leek, Egyptian celery & Chinese celery (as5%) these levels were reduced.
17- The best treatment to correct the level of GOT (AST) enzyme was observed for (group 5), Egyptian leek.