الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Pro-inflammatory cytokines, IL-1β and IL-6, were specifically
reported to be involved in the pathophysiology of INS. The chemokine IL-
6 was only recently documented to act as a soluble factor that increases
glomerular basement membrane permeability.
The aim of this study was to detect the role of IL-6 gene [G572C]
polymorphism in the etiology of nephrotic syndrome among the children
and the role of polymorphism in response to treatment.
The study constitutes 55 children suffering from an INS represent
the patients’ group classified into; Ia) Steroid responsive (37 patients), (Ib)
Steroid resistant (18 patients), and 50 healthy children represent the control
group matched in age and sex with the patients’ group.
Our results revealed that IL-6 [G572C] CC genotype and the C
allele were significantly more frequent among the patients group than the
control group. The IL-6 [G572C] CC genotype was also specifically
insignificant difference between steroid-resistant group and the steroidsensitive
group.
On comparison between patients and controls as regard genotype
frequency in the co-dominant model there is a statistically highly
significant difference of GC genotype (P <0.01), in the dominant model
there is a statistically very highly significant difference (P <0.001) as
regard CC+GC genotype and there is also a statistically very highly
significant difference between G and C genotypes in the alleles model.
On comparison between steroid sensitive and steroid resistant
patients as regard genotype frequency, there is a statistically insignificant
Summary & Conclusion
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difference (P>0.05) as regard the co-dominant model, dominant model,
recessive model and alleles.