الفهرس 
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Abstract
Phototherapy is generally considered a safe and well-tolerated treatment for hyperbilirubinaemia. However, clinical users should be aware of the unwanted effects of using phototherapy such as rash, loose stools, increased water loss.
The aim of this study was to evaluate the effect of intensive phototherapy on subsets of T lymphocytes through measuring the level of CD4 and CD8 lymphocytes subsets in newborns 6-8 hours after exposure to intensive phototherapy.
This study included 30 full term neonates with indirect hyperbilirubinemia in neonatal intensive care unit (NICU), and the control group included 20 healthy full term neonates.
Blood samples were obtained from hyperbilirubinemic neonates before phototherapy and 6-8 hours after exposure to intensive phototherapy and from controls at the examination time. The levels of CD4 and CD8 in peripheral blood were measured in the samples using immunophenotypic analysis by flow cytometry.
Our result showed that:
• There was no significant difference in CD4 and CD8 lymphocyte subsets level among patients before and 6-8 hours after exposure to intensive phototherapy .
• There was no significant differences between cases before phototherapy and control as regarding CD4% , CD8% and CD4/CD8 ratio .
• There was significant differences between cases after phototherapy and control as regarding CD8% ( p value 0.030) ,on the other hand there is no significant differences between cases after phototherapy and control as regarding CD4% and CD4/CD8 ratio.
• There was significant positive correlation between CD4% before phototherapy and age where (r value 0.398, p value 0.029 ) ,on the other hand there was no correlation between CD4% before phototherapy and other parameters(Birth Weight, Gestational age, Age of the mother, Hemoglobin, Platelets, Total leucocytic count, Total and Direct bilirubin ) and there was no correlation between CD4% and CD8 after phototherapy and all these parameters.