الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In fact it is the fourth most common cancer worldwide. People aged 50 and older are affected most frequently by this tumor.
The growing incidence of colon cancer in developed countries is mainly attributed to dietary factors (fat-rich, low-fiber diet) and a sedentary life-style.
During the past decades an increased interest has been demonstrated concerning the distribution of colon cancer through the different segments of the colon. A trend toward an increasing percentage of right-sided cancers has been reported, mainly by North American studies.
Multiple differences exist between left and right colon that could predispose to different biological, epidemiological and clinical assumptions concerning carcinogenesis and upon survival.
During embryologic development, the right colon (cecum, ascending colon, proximal two-thirds of the transverse colon) arises from the midgut, and the left colon (distal one-third of the transverse colon, descending and sigmoid colon, rectum) arises from the hindgut. This difference is reflected in the dual blood supply. It is well known that differences exist in gross macroscopic pathology between right-sided (RCCs) and left-sided colon cancers (LCCs).
RCCs are typically bulky, exophytic, polypoid lesions projecting into the lumen and causing significant anemia. LCCs are infiltrating, constricting lesions encircling the lumen, often leading to obstruction.9 Furthermore, several studies revealed a differential molecular biology pattern in colon cancers originating in the right and left colon (eg, DNA-euploidy status, Ki-Ras- and p-53 mutation rate).
The aim of the current study was to analyze the clinicopathological differences between left- and right-sided colonic tumors and to evaluate to which extent these differences affect the patient’s survival.
Our study included all stage I – IV colon cancer patients who were treated in Alexandria university hospitals from 2010-2015.
Our study confirms that right and left sided colonic tumors are essentially different.
In our population, right sided colon cancer patients were older with a significantly greater proportion of patients above 60 years of age, and were more likely women.
With colon cancers of the right side patients were more likely to have a positive family history for a first degeree relative with colon cancer.
Regarding symptomatology , left sided colonic tumors presented more by alteration of bowel habits , constipation , intestinal obstruction and fresh bleeding per rectum.
Meanwhile right sided colon cancer presented by rather vague complaints likel abdominal pain , anaemia and weight loss