الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 128 |  |  |
| | | from | 128 | | |
Abstract
Ventricular septal defect (VSD) is the most common congenital heart disease, accounting for 40% of all congenital heart diseases. Echocardiography is the investigation of choice for diagnosis of VSD. Although surgical option is the gold standard in management of ventricular septal defect, percutaneous closure is considered a suitable alternative in perimembranous ventricular septal defect.
The study included 25 patients with ventricular septal defect who were referred for percutaneous device closure to Ain Shams University Hospital from June 2015 till June 2018. Our study included 19 female patients (76%) and 6 male patients (24%). Patient age ranged from 2 years and 2 month to 17 years.
All patients included in the study performed full echocardiographic assessment, electrocardiogram and routine examination before, immediately, 6 months and at least a year after percutaneous closure.
Patients’ weight ranged from 11 to 65 kilograms with a median of 22 kilograms. Patients’ height ranged from 68 to 160 centimeter with a mean of 114.5 centimeters. Patient’s body surface area ranged from 0.48 to 1.65 with a mean body surface area of 0.85. Patients’ body mass index ranged from 12.5 to 26 Kg/m2 with a mean BMI 18.5.
Mean weight of patients increased from 22 to 26 Kg which was statistically significant with a P value of 0.002. With an overall mean increase of weight by 10%. Mean height of patients increased from 114.5 to 128 cm which was statistically significant with a P value of 0.001. With an overall increase of height by 6.2%.
Sequential echocardiographic follow-up showed highly significant decrease in LV dimensions and volumes, circumferential LV strain values, pulmonary to systemic circulation (Qp:Qs) ratio, RVSP and mPAP.
Significant complications occurred in (12%) of patients: symptomatic/significant Brady-arrhythmia (Complete heart block) that required permanent pacemaker implantation (4%), significant residual shunt causing hemolytic anemia requiring re-intervention (4%) and significant valvular regurgitation (4%) (Severe Tricuspid Regurgitation)
Percutaneous VSD closure is now an acceptable alternative to surgical closure of perimembranous VSD with very high procedural success rates.