الفهرس 
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Abstract
A potentiometric method based on modified screen-printed and modified carbon paste ion-
selective electrodes was described for the determination of clindamycin hydrochloride (CLINHC)
in different pharmaceutical and biological fluids (urine and serum). It is based on potentiometric
titration of CLINHC using modified carbon paste electrodes (MCPEs) and screen-printed
electrodes (MSPEs) as end point indicator sensors. The influences of the paste composition,
different conditioning parameters and foreign ions on the electrodes performance were
investigated and response time of the electrodes has been studied. The electrodes showed
nernstian response of 58.97 ± 0.907, 60.83 ± 0.931,58.46 ± 0.808 and 59.14 ±0.766 mV decade”
in the concentration range of 7 .94x I 0,7-1 x 10’2 and 1 x l 0’7-1 x 10’2 mol L’I for MCPE (electrodes I
and Il) and MSPE (electrodes III and IV), respectively. The electrodes were found to be usable
within the pH range of2.0-8.0 and 2.0-9.0. They exhibited a fast response time (about 11 and 9 s),
low detection limit of 7.94 x 10,7 and 1.0 x 10’7 mol L’I, long lifetime (74, 61 and 144, 165 days)
for MCPE (electrodes I and 11) and MSPE (electrodes III and IV), respectively. The electrodes
were successfully applied for the determination of CLINHC in pharmaceutical preparation and
biological fluids (urine and serum). The results obtained applying these potentiometric electrodes
are comparable with British pharmacopeia. The method validation parameters were optimized and
the method can be applied for routine analysis ofCLINHC drug.
Keywords: Modified carbon paste electrodes; Modified screen-printed electrodes; Determination