الفهرس 
PSORIASISOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a chronic inflammatory disease that occurs in about 0.1% - 3% of the population. It is characterized by an immune-related pathogenesis, a genetic background which may be triggered by several environmental factors including smoking and infections leading to a T cell-mediated cytokine production that drives hyper proliferation and abnormal differentiation of keratinocytes.
Osteopontin (OPN) is a multifunctional glycopho-sphoprotein secreted by many cell types, including osteoblasts, lymphocytes, macrophages, epithelial cells and vascular smooth muscle cells. It has been demonstrated that OPN modulates inflammatory processes involved in psoriasis, which is the most prevalent T-cell mediated inflammatory disease in humans through its action as chemotactic factor, supporting the adhesion and modulating the function of T cells and monocytes/macrophages.
Phototherapy is an essential therapeutic option for patients with psoriasis and has been used for more than 75 years. The most commonly used types of phototherapy are photochemotherapy using psoralen ultraviolet A (PUVA) and Narrow band ultraviolet B (NB-UVB) therapy.
The aim of work is to assess the level of serum OPN in psoriatic patients to determine their possible role in the pathogenesis of psoriasis and to evaluate the change in its level after phototherapy.
This study included 45 subjects (30 patients with psoriasis (16 males and 14 females) with age ranged between 19 and 60 years with a mean of (45.5 ± 11.3) and 15 healthy controls their age ranged between17 and 55 years with mean of 34.9 ± 9.9. the psoriatic patients were divided into two groups, the first was treated by PUVA and the second was treated by NB-UVB. The levels of serum OPN were measured in the psoriatic patients and in the controls by ELISA technique.
Regarding Osteopontin level, it was significantly higher in psoriatic patients compared to controls. However, there was no significant difference in OPN level among psoriatic patients according to PASI score. Moreover, OPN levels in the present study were significantly correlated with BMI of psoriatic patients since patients with >25 BMI showed higher levels of OPN than patients with ≤25. Besides, OPN level decreased in both groups after therapy but there was no significance difference between the two treatment modalities. No significance difference was found in OPN level among psoriatic patients according to different studied clinical and laboratory parameters.
The results of this study confirmed the role of OPN in psoriasis and the limited effect of photo(chemo)therapy on its levels.