الفهرس 
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Abstract
Atopic dermatitis (AD) is an inflammatory skin disease, that characterized by pruritus and recurrent eczematous reaction with a chronic disease course. It has acomplex pathogenesis depends on the interaction between environmental and genetic factors ending in disturbances in the immune system and disruption of the epidermal barrier.
Adipokines are biologically active agents that are mainly produced in adipose tissue. There is evidence, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. These adipokines include hormones (e.g leptin and adiponectin), cytokines (e.g TNF-, IL-6, IL-10, and visfatin), and other proteins (e.g apelin and resistin), which participate in many physiological and pathological processes. Resistin has been suggested to be an important link between obesity and insulin resistance. Also, it has an important regulatory role in a variety of biological processes including atopic dermatitis.
The current study aimed to shed light on the hypothesized role of resistin in aetiopathogenesis of atopic dermatitis through evaluation of its serum level and SNP in AD patients, in addition to correlate its estimated results with the available clinical aspects of AD in those patients.
Our study included 45 patients with AD and 40 healthy controls of matched age and sex. For all participiants; history, general and dermatological examination were performed. SCORAD score was used to assess AD severity. Moreover, CBC, ELISA and PCR-RFLP were performed to detect leukocytic count, serum resistin levels and resistin rs3745367 SNP resectively.
The result of the current study showed that:
1. In AD there were statistically significant lower levels of serum resistin than that of control group.
2. There were significant associations between low serum resistin and AD severity, presence of leucocytosis and positive AD family history.
3. Resistin rs3745367 GG genotype and its G allele were significantly demonstrared in AD patients than in controls.
4. Resistin rs3745367 GG genotype carriers were significantly associated with severe disease, positive AD family history and presence of leukocytosis, as well as low serum resistin levels.