الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Autism is a medical term of one of the neurodevelopmental disorders of childhood typically characterized by substantial impairments in social skills and verbal and non-verbal communications, restricted interests, and repetitive behaviors (Elbahaaey et al., 2016).Autism is a chronic disorder with an onset before the age of 3 years, (El-Baz et al., 2011).Susceptibility to autism has been suggested to be attributable to genetic factors and environmental risk factors but the etiology of the disorder is poorly understood. Immune aberrations consistent with a dysregulated immune response have been reported in autistic children (Wei et al., 2012).Due to the high social significance of autism and the arising frequency, clinical practice has long sought to shade a light on etiology and pathogenesis of this disorder which still remain elusive. Until the etiology of autism is known, it will be difficult to identify effective prevention and treatment. Current belief holds that autism derive generically from a complex interaction between genetic, epigenetic and environmental factors (Engel and Daniels, 2011).Some studies suggest that a combination of environmental risk factors, autoimmune conditions and localized inflammation of the central nervous system may contribute to the pathogenesis of autism (Wei et al., 2011).A dysregulated immune response has been reported among children with autism. Protein products of immune activation, such as cytokines, can be linked to core features of autism spectrum, such as difficulties to regulate affect, sleep, nutritional uptake, and can also affect behavior and social communication (Ashwood et al., 2006).IL-6 is a Pro-inflammatory cytokines that can trigger cellular responses that mediate inflammation, neurogenesis, gliogenesis, cell growth, cell survival, myelination, and demyelination in the CNS. IL-6 can impact processes in the adult brain, and physiological levels are critical for homeostasis, cognition, learning, and memory. Physiological levels of IL-6 are critical for normal CNS function, and both over and under expression leads to neurological problems (Goines and Ashwood, 2013).