الفهرس 
Antibacterial activityOnly 14 pages are availabe for public view
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Abstract
In the first ligand, Cr (III), Mn (II), Co (II), Ni (II), Cu (II), Zn (II), Cd (II), Ca(II), Fe(III), Hg(II), Pb(II), and Bi(III) complexes of (E)-2- ((1-(5-acetyl-2,4-dihydroxy phenyl) ethylidene) amino) benzoic acid were prepared and characterized by elemental analyses, IR, UV-Vis spectra, Magnetic moments, Conductivity, 1H-NMR and Mass spectra, Thermal analyses (DTA and TGA) and ESR measurements. The analytical and IR data showed that, the ligand behaves as neutral monobasic tridentate. Molar conductivity in DMF indicate that, the complexes are non-electrolytes. ESR spectra of solid Cu(II) complexes at room temperature show axial type (dx2-y2) with covalent bond character in an octahedral environment. However, Co(II), Fe(III) and Mn(II) complexes showed isotropic type. Complexes showed inhibitory activity against human breast cancer (MCF-7 cell line) compared with standard drug. Also, the Zn(II) complex (8) showed a high potency of inhibition (89.47%) at 500μg/ml against MCF-7cell line, (81.04%) at 250μg/ml, (69.33%) at 125μg/ml compared with a standard drug. Zn(II) complex (8) demonstrated the highest potency inhibition activity among all tested compounds against MCF-7 cell line with IC50 (50.2) μg. While in the second ligand, Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Ca(II) complexes of sodium 4,4-(((((1E, 1E)-((4,6-dihydroxy-1,3-phenylene) bis (ethan-1-y1-1-ylidene)) bis (azanylyidene)) bis (ethan-2,1-diyl)) bis (azanediyl)) bis (carbonyl)) diphenolate were prepared and characterized by elemental analyses, IR, UV-Vis spectra, Magnetic moments, Conductivity, 1H-NMR and Mass spectra, Thermal analyses (DTA and TGA) and ESR measurements. The analytical and IR data