الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Cancer is group of diseases characterized by the spread of abnormal cellsand their uncontrolled growth.
If the spread is not controlled, it can result in death. One of the most common cancers is breast cancer and it has a high incidence rate in all countries.
The main linesof treatment for breast cancer are radiation therapy (RT), chemotherapy (CT), endocrine, hormone therapy (ET), surgery and targeted therapy.
Negative impact on health related quality of lifeis the result of the several chemotherapy adverse effects such as hair loss, depressed immunity, fatigue, gastrointestinal disturbances and neutropenia haveNanoparticles (NPs) show interesting characteristics as small sizes, large surface-to-volume ratios, high drug loadingcapacity, self-assembly capacity, and biocompatibility.Consequently, they have the potential to increase bothselectivity and potency of chemical, physical, and biological approaches for eliciting cancer cell death while lowering thecollateral toxicity to nonmalignant cells.
Natural polymers have exceptional properties including biodegradability, non-antigenicity, compatibility, high nutritional value, abundant renewable sources, good tailoring ability and extraordinary binding capacity of various drugs for a wide range of clinical application.
Lactoferrin is an iron-binding glycoprotein of transferrin family of iron transporter proteins that regulates the concentration of iron ions in blood and secretory fluids, exerts antimicrobial and antiviral action and is considered as an important immune factor of milk.
In addition, lactoferrin is easy to purify and soluble in water allowing ease of delivery by injection and shows an ideal candidate for NPs preparation.In this study, we presented thesynthesis andthe co-delivery of ellagic acid (EA) and pemetrexed (PMT) in breast cancer targeted mesoporous silica nanoparticles(MSNPs).
Lactoferrin was attachedat the surface of MSNPs as a targeting ligandusing chemical bioconjugation reactions to form stable amide bonds.
The combinational therapy of EA and PMT showeda successful synergistic combination.
Condensation\polymerization and amide bond formation bioconjugation reactions were the basis for the synthesis of MSNPs and the loading of both the drug and the targeting ligand.