![]() | Only 14 pages are availabe for public view |
Abstract The thesis consists of 185 pages and comprises 41 tables, 50 figures and 189. The thesis consists of four parts : <Part I : This part contains a general introduction about the chemical names, structures, physical properties, pharmacological actions, uses and literature reviews for their reported methods of analysis. Part II : This part dealt with the analysis of the newly approved complex of valsartan and Sacubitril using spectrofluorimetric and spectrophotometric methods. Chapter 1: This chapter aimed at the determination of Valsartan and Sacubitril in their tablets. First derivative spectrofluorimetric method was developed. <Chapter 2: This study aimed at the estimation of Valsartan and Sacubitril in their tablets using second derivative, convolution after first derivative and first derivative ratio spectrophotometric methods. <Part III: <This part dealt with thechromatographic analysis of VAL and SAC either in presence of their degradation products through stability indicating method or in presence of SAC related substance. <Chapter 1: <This chapter described stability-indicating method for the determination of LCZ696using HPLC-DAD method. The method was applied to the kinetic investigation of SAC. <Chapter 2: This chapter analyze VAL and SAC along with SAC related substance by using HPTLC and HPLC with two different detectors. <Part IV: This part dealt with the electrochemical determination of selected drugs in their biological fluids using hanging mercury electrode. Chapter 1: Valsartan (VAL) can be analyzed at mercury electrode in the presence of nickel (II) permitting the analysis of VAL in its pharmaceutical formulation and human urine. Chapter 2: Differential pulse polarographic method has been developed for determination of dantrolene sodium and indomethacin in rat plasma |