الفهرس 
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Abstract
This work was conducted to study the effect of respiratory affections in sheep and
their associated bacteriological, hematological ,biochemical , immunological and
antioxidant changes .A total 150 samples ( nasal swabs, ocular swabs and blood
samples) were collected from 30 sheep of 2 farms of different ages (2-7 months)
(apparently healthy & diseased sheep before and after treatment by using sulphatrimethoprim
, kanamycin 25 %, ketoprofen and AD3E.While, Farm B were treated
with oxytetracycline20%L.A, sulphadimidine 33.3 %, declophen5% and AD3E for 5
days treatment).
The isolated bacterial pathogens from farm A were Enterobacter cloacae and
Pasteurella multocida in percentage (80% and 50%), Pasteurella haemolytica and
Klebsiella pneumoniae in percentage (30% and 60%) respectively.
Concerning the hematological findings of farm A revealed significant decreases in Hb
content, PCV percent, MCH, MCV and MCHC leading to microcytic hypochromic
anemia (iron deficiency anemia) and thrombocytopenia with significant increase in
T.L.C coupled with lymphocytosis, monocytosis, eosinophilia and neutropenia. While,
farm B showed significant decrease in RBCS count, Hb content, PCV % with
significant increase in MCV with decrease in MCHC
(regenerative stage of hemorrhagic anemia) as well as thrombocytopenia. Marked
T.L.C with neutrophilia, monocytosis and eosinophilia with lymphocytopenia.
Additionally, the parameters of erythrogram and leucogram showed improvement post
treatment.
Serum biochemical examination of farms A&B revealed significant elevation in liver
enzymatic activities of AST, ALT, ALP, GGT, LDH and total biliruben with
significant decrease in total protein and albumin with significant increase in globulin,
urea and creatinine.
Immunological results in farm A showed marked increase in Interlukin10 (IL-10) and
insignificant change in Interleukin 1β (IL-1β) which improved after treatment. While,
farm B showed marked increase in (IL-1β) and insignificant change in (IL-10).
The study included oxidative changes in which farm A&B revealed marked increase in
lipid peroxide (MDA) and decrease in Total antioxidant capacity (TAC) which
improved after treatment.