الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Background: The rising numbers of patients with liver injury caused by many reasons such as usage of drugs, alcohol and malnutrition which induced an excessive production of free radicals which are responsible for several lived diseases, recent investigations have proved the important role of antioxidants to ameliorate the damage caused by these compounds. In addition, there is a great attention for usage of herbal medicine in treatment of liver disease. Objective: The present comparative study was carried out to evaluate the hepato-protective effect of Ginkgo biloba leaf extract (GbE) against hepatotoxicity induced experimentally by CCl4 and comparing these effects with a reference drug (Legalon) that used commonly in Egypt to treat liver disorders. Methods: Animals were treated orally with GbE at a dose of (100ml/kg) and Legalon drug at a dose (100ml/kg), once daily for one week before the first dose of CCl4. Thereafter, liver fibrosis was induced by oral administration of CCl4 at a dose of (2.5 ml/kg) in olive oil day after day for 8 weeks, and the administration of GbE and Legalon was continued at the same doses and duration. At the end of the experiment, biochemical indices changes and histopathological studies were examined to evaluate the protective effect of GbE. Results: showed that CCl4 induced a significant (P>0.5) increase in ALT, AST, ALP, MDA and lipid profile as compared with control group While, TP, alb, HDL, TAC, GSH, GPx, CAT and SOD showed a significant decrease when compared with control group. On the other hand, treatment with GbE caused alterations to all of these parameters when compared with both CCl4-intoxicated group and Legalon group. All of these results were confirmed with the histopathological investigations._pre-treatment of the animals with GbE improved the liver damage that induced experimentally by CCl4. The biochemical parameters and the histopathological studies showed that GbE plays an important role as a potent antioxidant; it causes suppression of the oxidative stress, which subsequently leading to ameliorate hepatotoxicity and counteracting the progress of liver fibrosis.