الفهرس 
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Abstract
The present study aimed to compare the efficacy of 2% minocycline and
25 microgram per milliliter (µg/ml) nanosilver gel, locally applied to induced
periodontitis in rats, through clinical, microbiological, radiographical and
histopathological results.
Material and methods: One hundred and ten male albino rats were included. group I
(healthy or negative control group): consisted of 10 healthy rats without induction of
periodontitis. After induction of experimental periodontitis (EPD) using elastic ring,
rats were randomly divided into the following experimental groups. group II (positive
control group): consisted of 40 rats with experimentally- induced periodontitis
(infected but not treated. group III (nanosilver group): consisted of 30 rats, animals
subjected to EPD and treated with 25 µg/ml gel once daily. group IV (minocycline
group): consisted of 30 rats, animals subjected to EPD and treated with 2%
minocycline once daily. Baseline assessment was conducted on day 0 (before any
treatment). Evaluation of the inflammation during drug treatment was conducted on
days 7, 15 and 30). At all-time points, clinical evaluation was performed to evaluate
the extent of gingival inflammation and grade of mobility. Direct examination of
bacterial cultures was performed at each time point for microbiological study. Ten
rats from each group were euthanized at each time point for radiographic and
histopathological assessment.
Results: Nanosilver gel showed a superior antibacterial effect compared to
minocycline gel in terms of improvement of clinical scores, microbial counting
(reduced colony forming units), radiographic result, as well as histopathological
findings (regarding significant reduction of inflammatory cell count and significant
bone regeneration).
Conclusion: Nanosilver gel in a concentration of 25 µg/ml is a promising ca