الفهرس | Only 14 pages are availabe for public view |
Abstract The present study aimed to compare the efficacy of 2% minocycline and 25 microgram per milliliter (µg/ml) nanosilver gel, locally applied to induced periodontitis in rats, through clinical, microbiological, radiographical and histopathological results. Material and methods: One hundred and ten male albino rats were included. group I (healthy or negative control group): consisted of 10 healthy rats without induction of periodontitis. After induction of experimental periodontitis (EPD) using elastic ring, rats were randomly divided into the following experimental groups. group II (positive control group): consisted of 40 rats with experimentally- induced periodontitis (infected but not treated. group III (nanosilver group): consisted of 30 rats, animals subjected to EPD and treated with 25 µg/ml gel once daily. group IV (minocycline group): consisted of 30 rats, animals subjected to EPD and treated with 2% minocycline once daily. Baseline assessment was conducted on day 0 (before any treatment). Evaluation of the inflammation during drug treatment was conducted on days 7, 15 and 30). At all-time points, clinical evaluation was performed to evaluate the extent of gingival inflammation and grade of mobility. Direct examination of bacterial cultures was performed at each time point for microbiological study. Ten rats from each group were euthanized at each time point for radiographic and histopathological assessment. Results: Nanosilver gel showed a superior antibacterial effect compared to minocycline gel in terms of improvement of clinical scores, microbial counting (reduced colony forming units), radiographic result, as well as histopathological findings (regarding significant reduction of inflammatory cell count and significant bone regeneration). Conclusion: Nanosilver gel in a concentration of 25 µg/ml is a promising ca |