الفهرس 
NON ALCOHOLIC FATTY LIVER DISEASEOnly 14 pages are availabe for public view
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Abstract
SUMMARY AND CONCLUSION
Non-alcoholic fatty liver disease (NAFLD) is an umbrella term and includes the simple deposition of adipose tissue in the liver to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases hepatocellular carcinoma (HCC)(13).
As obesity becomes an epidemic across the world, NAFLD is not only a risk factor for hepatic failure and hepatic carcinoma, but it is also associated with a spectrum of extrahepatic diseases generally linked to metabolic syndrome (MetS) such as type 2 diabetes, cardiovascular disease (CVD)and renal disease(169-170) .
Emerging evidence suggests that subjects with NAFLD have an increased risk of chronic kidney disease (CKD). In this regard, the close relationship between NAFLD and CKD recently has gained considerable scientific interest.
Classical methods of assessing kidney function include measurement of serum urea nitrogen, creatinine, estimated glomerular filtration rate, and biomarkers which are poor sensitive and nonspecific.
Many studies show that kidney injury molecule-1(KIM-1) is a sensitive and specific marker of kidney injury as well as a predictor of prognosis especially in acute kidney injury.
The aim of the study was to determine early renal functional alterations in overweight / obese children and adolescents with (NAFLD), as assessed by measuring urinary KIM-1 level, and to evaluate its relation to the degree and various clinico-laboratory parameters of NAFLD.
This study was conducted on 60 overweight / obese children and adolescents .Their ages ranged between(4.5-16) years. They were divided