الفهرس 
Acute kidney injury
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Abstract
Hyperphosphatemia has been reported to induce
extraskeletal calcification of soft tissue particularly in the heart as well as
bone disease; a link has been reported between gastric hyperacidity and
hyperphosphatemia in patients with renal dieses undergoing hemodialysi.
Objective: The purpose of this study was to compare the effect of
Famotidine versus Omeprazole on the efficacy of calcium carbonate as
phosphate binder in haemodialysis patients.
Methods: from February 2014 to June 2014 total number of 64 patients of
both sexes were recruited from Department of Renal Dialysis, Tanta
University Hospital, Egypt. Patients were categorized into 3 groups.
group I (control group) consisted of 20 Patients (10) females and (10)
males took calcium carbonate (CaCO3) (2.5 – 4 g/day) only, group II
consisted of 21 Patients (13) females and (8) males took the same dose of
CaCO3 with famotidine 10 mg/day and group III consisted of 23 Patients
(8) females and (15) male took the same dose CaCO3 with omeprazole 20
mg/day. 5 ml blood was collected from antecubital vein by 5 ml syringe at
the start of the study and monthly for four monthes during hemodialysis
sessions for the assessment of serum calcium, phosphorus, alkaline
phosphates and parathyroid hormone levels.
Results: All data are expressed as the mean ±SD. group II showed
significant increase (p< 0.05) in serum phosphorus at 3rd month with
significant decreased (p< 0.05) in serum calcium comparing with
pretreatment value was detected, howeever no significant change in
parathyroid hormone (PTH) level.
Abstract
II
group III showed no significant change in serum calcium, phosphorus and
PTH levels comparing with pretreatment values. Both groups (II and III)
showed significant decrease in alkaline phosphatase (ALP) level (p<
0.05).
Conclusion: Co-administration of famotidine with calcium carbonate
aggravates hyperphosphatemia and this may increase the incidence of
complications. The efficacy of calcium carbonate as a phosphate binder was
not affected by co-administration of omeprazole.