الفهرس 
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Abstract
The aim of the present study work was quantitative determination of ceftiofur and diclofenac residues in different rabbit tissues (liver, kidney, lung , muscle , heart , spleen and blood) following intramuscular administrations of these drugs at dose 2.2mg/kg b.wt once daily for ceftiofur and 1.5mg/kgb.wt twice daily for diclofenac. Also make intrest on effect of diclofenac on residues of ceftiofur in rabbit tissues. High performance liquid chromatography and liquid – liquid extraction were used for determining both of antibiotic and anti-inflammatory residues concentration in serum and tissue samples .
Results: Ceftiofur: According to the established MRL of ceftiofur recommended by EMEA/CVMP which is 1000, 2000 and 6000μg/kg in muscle, liver and kidney, respectively. We found that rabbit tissues are lower than the recommended MRL at after last dose of drug administration to be safe for human consumption . without any health hazards on consumers
Diclofenac: Diclofenac remained within detectable limit till the 3rd day in most examined tissues, while in muscle and kidney it still remained till the 5th day post cessation of drug administration .
According to the established maximal residual limits (MRLs) for each drug to ensure consumers safety.
Effect of diclofenac co-administration with ceftiofur on residues of ceftiofur in examined rabbit tissues . There is wide distribution of ceftiofur in tested tissue after co- administration of ceftiofur with diclofenac .
There are no significance changes between ceftiofur alone or with ceftiofur administrated with diclofenac except in muscle continued to 5thday after cessation of drug administration but lower than MRL . So It may be concluded that diclofenac may be successfully co-administrated with ceftiofur for combating inflammatory conditions without alterations of the dosage regimen of ceftiofur. without harmful effect on human consumption.