الفهرس 
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Abstract
Acne is a common and complex skin disorder that distresses many patients because of its chronicity. Although multiple factors contribute to acne development, chronic inflammation is an important mechanism. Several inflammatory mediators such as cytokines, defensins, and neuropeptides have been identified in acne lesions.In addition, P.acnes triggers cytokine activation by Toll-like receptors, which means that the innate immune system is also important for acne development.
Vitamin D plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis , psoriasis and alopecia areata.However, the association with acne remains unclear.
The aim of this study was to evaluate the serum 25-(OH) D level in males with acne vulgaris and correlate the estimated level with the disease severity.
The present study is a case-control study and included two groups. The first group included 30 male patients with acne, the second group included 30 healthy volunteers matched for age, skin phototype, socioeconomic status, and outdoor exposure.
Among these 30 patients, 1patient (3.3%) was presented with sufficient levels of vitamin D3, 13 patients (43.3%) were presented with insufficient levels of vitamin D3 and 16 patients (53.3%) were presented with deficient levels of vitamin D3. On the other hand, 19 (63.35%) of control volunteers had insufficient levels of vitamin D3, 11(36.7%) had deficient levels and no one had sufficient level(0%).
In this current study, the mean level of vitamin D3, in patients, was 20.10 ng/ml and ranged from 8.90 to 38.40 ng/ml. But the mean level of vitamin D3, in controls, was 22.36 ng/ml and ranged from11.60 to 29.10 ng/ml. The difference between both groups was statistically insignificant.
Furthermore, no statistically significant correlations were found between the level of vitamin D and patientsˈages , disease duration, BMI,family history, sun exposure time ,trunk involvement and acne severity.