الفهرس 
Hepatitis C Virus Infection in Egypt and chronic HepatitisOnly 14 pages are availabe for public view
 |  | from | 135 |  |  |
| | | from | 135 | | |
Abstract
Background and Aims: Hepatitis C virus (HCV) poses a real health threat being one of the most prominent causes of chronic liver diseases worldwide. In Egypt, however, the situation is even more critical. Egypt has a higher prevalence for HCV than any other country in the world with a similar socioeconomic situation and hygienic conditions. Hepatitis C remains an important source of morbidity and mortality among the Egyptians. Little is known about the Cardiac effects of antiviral therapy in chronic Hepatitis C patients. we studied the possible cardiac effects of direct antiviral drugs “sofosbuvir & daclatasvir” on Egyptian HCV patients.
Methods: The study was conducted on 40 patients diagnosed with chronic HCV infection, recruited from the outpatient clinics National committee for combating Hepatitis C virus, Ain shams University unit, starting from July 2018 till December 2018. Patients were divided into two groups: group IA: Cirrhotic patient received Antiviral drugs without risk factors for cardiac affection.
group IB: Cirrhotic patient received Antiviral drugs with risk factors for cardiac affection (as DM, HTN, OBESITY, DYSLIPIDIMIA). group IIA: Non-Cirrhotic patient received Antiviral drugs without risk factors for cardiac affection. group IIB: Non-Cirrhotic patient received Antiviral drugs with risk factors for cardiac affection (as DM, HTN, OBESITY, DYSLIPIDIMIA).
Results: There was significant difference between 2 groups regarding hemodynamics across the tricuspid valve in the form of valve regurgitation . RVSP was significantly increased among the groups of the study especially among the patients with CVS risk factors.
CONCLUSION :New HCV treatment with directly acting antiviral agents proved not only its efficacy in management of chronic HCV in Egyptian patients but also proved its safety on the heart with most of its applied regimens. Although, in some patients show different degrees of decrease heart rate , proved by Electrocardiogram , these changes was reversible after stoppage of treatment without leaving any permenant cardiac damage.