الفهرس 
Subjects and methodsOnly 14 pages are availabe for public view
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Abstract
Background: Catheter associated urinary tract infection (CAUTIs) is one of the most predominant health care associated infections, 17.5% of admitted patients had a catheter for particular period of time. Approximately there is 5% daily risk of acquiring infection in 25 % of short-term catheterized patients versus 100% daily risk in long-term catheterization. CAUTIs can lead to numerous medical complications such as bladder stones, septicemia and pyelonephritis. Biofilms can form on different medical implants. It has been estimated that biofilms are associated with 65% of nosocomial infections and that treatment of these biofilm-based infections costs >$1 billion annually. Aim: This work was carried out to detect, characterize biofilms, determine drug susceptibility pattern of isolated pathogens from indwelling urinary catheters and study risk factors affecting catheter associated urinary tract infections (CAUTI) among patients at Urology and Nephrology Centre, Mansoura University. Setting: Microbiology Diagnostics and Infection Control Unit (MDICU), in the Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University. Results: This study was conducted over a period of 12 months from October 2017 till September 2018, and it included 105 CAUTIs patients out of 600 patients admitted to Urology and Nephrology Centre, Mansoura University with total prevalence 17.5%. Klebsiella pneumoniae was the most common isolated organisms. CAUTI was predominant in male more than female.Biofilm producers formed (79.23%) of all bacterial isolates. Klebsiella pneumonaie was the highest biofilm producer. High rate of biofilm production was observed in latex more than silicon catheters.Multi drug resistant organisms were higher in biofilm producers than in non-biofilm producers. Conclusion:. CAUTIs caused by biofilm producers uropathogens are more resistant to antibiotics and are difficult to be eradicated. Cefuroxime showed the highest resistance pattern among all bacterial isolates. Urinary catheters especially latex formed a good medium of biofilm formation leading to high rates of infections. Prolonged duration of catheterization resulted in elevating the risk of developing CAUTIs and biofilm formation. Tube method was reliable to be used in routine laboratory investigations for biofilm detection as it showed good correlation with scanning electron microscope.