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Abstract Aim of the work: to perform thyroid screening program to high risk preterm babies for early detection, prevention and treatment of the deleterious effect of hypothyroidism on the neurodevelopment of the child Patients and methods: All subjects of this study were subjected to thorough medical history and clinical examination Lab investigations include: 1-TSH level as the first screening according to Egyptian National Screening Program. 2- Hypothyroidism was diagnosed when TSH level is more than 15 mIU/L -If the first screening was abnormal, we withdraw serum sample for rescreening and start l-thyroxin therapy immediately. -If the second screening was abnormal, l-thyroxin therapy is continued.-If the first screening is normal, a second sample was withdrawn 4 weeks later, if the second screening was normal, the baby did not have hypothyroidism. -If the second screening was abnormal, the baby was initiated on l-thyroxin therapy. Results: there was significant difference for rescreening in revealing hypothyroid cases among the study group versus first screening. from our study, we concluded the importance of screening preterm babies and applying rescreening 4 weeks later for early detection and management of congenital hypothyroidism. |