الفهرس | Only 14 pages are availabe for public view |
Abstract Aim: This prospective study aims to investigate the serum concentrations of CA-125 in normal and preeclamptic pregnancies and thus to specify the value of this biochemical marker in prediction and diagnosis of preeclampsia. Methods: This study reviews a total of 72 primigravid women with singleton pregnancy. These participants were categorized into two groups: control (n = 36) and preeclampsia (n = 36). Results: Serum CA-125 concentrations were found to correlate positively with diastolic blood pressure (r = 0.345, Pvalue < 0.001) and maternal age (r = 0.052, P-value = 0.002) but no significant correlation was found with systolic blood pressure, platelet count and gestational age at time of delivery. When the cut-off point for serum CA-125 concentration was accepted as 51.38 IU/ml, the sensitivity and specificity of this biochemical marker were, respectively, 63.9% and 97.2% for the detection of preeclamptic pregnancies. On the other hand, positive and negative predictive values for CA-125 were 95.8% and 72.9%, respectively. Conclusion: This study suggests that CA-125 is a biochemical marker which reflects the underlying inflammatory process in preeclampsia. Keywords: CA-125 – Preeclampsia – Pregnancy . |