الفهرس 
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Abstract
Cryptosporidium parvum is a highly prevalent worldwide protozoan parasite (Reina et al., 2016) that is known to be the most important cause of enteritis in humans (Mohammadpour et al., 2016) and the 2nd most common cause of watery diarrhea ranking immediately after rotavirus in Asian and African children (Ryan et al., 2016). Disease severity depends on parasite virulence, site of infection, age and immune status of the host (Benamrouz et al., 2012 a).
The potential carcinogenic effect of cryptosporidiosis is a serious complication of this disease (Creusy et al., 2010). An association between cryptosporidiosis and cancer whether direct or indirect was detected in many studies (Benamrouz et al., 2014). Besides, C. parvum infection can alter the gene expression profile of the host cell (Liu et al., 2009). Defects in the Wnt/ β- catenin dependent signaling pathway are an initiating event in many pre-neoplastic lesions (Conteduca et al., 2013).
The aim of this study was to detect the potential ability of C. parvum to induce neoplastic changes in the GIT epithelium of experimentally infected mice (immune-competent and immune-suppressed groups) and the role of β-catenin dependent Wnt pathway as a possible mechanism of tumor induction. Also, it investigated the effect of treatment with NTZ on pathological changes and level of β-catenin gene expression.
This study included