الفهرس 
HEPATITIS C VIRUSOnly 14 pages are availabe for public view
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Abstract
Background: chronic viral hepatitis infection is associated with wide metabolic disarrangements. HCV interacts with lipid metabolism leading to steatosis, causing wide adipocytokines changes and impairs glucose metabolism leading to increased prevalence of insulin resistance (IR) and type 2 diabetes. This association is important, because several studies have shown that the presence of IR is associated with increased rates of fibrosis. And lower rates of rapid and sustained response to antiviral therapy. Aims: The aim of this study is to evaluate the Impact of Direct Acting Antivirals. Therapy on serum leptin level in Egyptian patients with chronic hepatitis C infection in correlation with fibroscan as a marker of hepatic fibrosis.
Patients and methods: 50 subjects were divided into 2 groups: group 1: 10 normal people (control group). group 2: 40 patients with chronic hepatitis C virus infection treated with DAAs (Sofosbuvir & Daclatasvir ± Ribavirin) for 3 months. All patients was subjected to leptin level measurement before and after treatment correlation with fibroscanin addition to measurement of leptin level in control group.
Results: leptin level among cases ranging from 50 to 140 pg/ml with mean (94.625±23.132) while among control from 20 to 95 pg/ml with mean (56.600±26.467), unlike leptin level among the studied cases group before treatment ranging from 50 to 140 pg/dl with mean 94.625±23.132 pg/ml while after treatment ranging from 50 to 135 pg/ml with mean (92.500±25.013) .the mean difference between pretreatment and 12 weeks post treatment is 2.125±16.008 pg/ml with p value of 0.406.fibrosis degree among the studied cases group before treatment ranging from 4.8 to 20.6 kPa with mean (10.348±4.510kPa) while after treatment from 3 to 14.4 kPa with mean (7.875±3.382 kPa). the mean difference between pretreatment and 12 weeks post treatment is 2.473±1.870 kPa with P value of <0.001* denoting statistically significant difference as fibrosis degree markedly decreased after treatment with lower post treatment fibrosis stage in correlation to pretreatment stage. Conclusion: Serum leptin was found to be higher in chronic hepatitis c than normal person but there was no difference between pretreatment and post treatment level,in contrast tofibroscan which showed marked reduction of fibrosis degree after treatment with DAAs and SVR