الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) infection is a blood borne infection The diagnosis of HCV infection is made by the detection of antibodies against HCV (anti-HCV) and/or by detecting the presence of the HCV RNA in serum (lawerance et al,. 2017).
Genotype 4 of HCV is the main genotype in Egypt as represent about 93% and other HCV genotypes as genotypes 1 and 3 have low distribution as they represent 6% and 1% respectively.
The liver is the main site of virus replication but it can also replicate at extrahepatic sites such as peripheral blood mononuclear cells (Carreño et al., 2012)
Functional gastrointestinal disorders are diagnosed and classified using the Rome criteria; the criteria may change over time as new scientific data emerge. The Rome IV was released in May 2016. The aim is to review the main changes in Rome IV. FGIDs are now called disorders of gut-brain interaction. Rome IV has a multicultural rather than a Western-culture focus. There are new chapters including multicultural, age-gender-women’s health, intestinal microenvironment, biopsychosocial, and centrally mediated disorders
Various abnormalities in gastrointestinal structure and function have been described in patients with chronic liver diseases, including altered gastrointestinal motility, intestinal permeability and absorption. While these changes may not be as clinically overt as other common complications of chronic liver diseases, they not only influence nutritional status, but can also contribute to clinical complications such as hepatic encephalopathy and spontaneous bacterial peritonitis.
Dyspepsia is a common clinical problem encountered by both primary care physicians and gastroenterologists and a very frequent phenomenon in hepatitis C patients (HCV).(Ahlawat SK, Richard Locke G,)1The global prevalence of un-investigated dyspepsia is 21% but varies among countries. Prevalence is significantly higher in women, smokers, NSAID users, H.pylori positive individuals and patients with liver cirrhosis.
FD is a prevalent finding in HCV patients and its pattern is not different from that of the general population. FD is more prevalent in patients with chronic hepatitis C. Obese, chronic HCV patients with high level with education and. With higher fibrosis scores are more likely to have FD
Patients with chronic hepatitis C often suffer from different abdominal complaints. In the present study, we find that abdominal complaints in hepatitis C patients could be of functional origin, as IBS is a prevalent finding in patients with hepatitis C genotype 4 in our locality, and In HCV IBS patients, we found that IBS-C and IBS-M are the predominant types.