الفهرس 
NORMAL AND ABNORMAL FETAL GROWTHOnly 14 pages are availabe for public view
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Abstract
Thyroid hormones affect renal development and physiology. Hyperthyroidism accelerates several physiologic processes, a fact which is reflected in the decreased systemic vascular resistance, increased cardiac output (CO), increased renal blood flow (RBF). Hypothyroidism has a more negative influence on kidney function. Peripheral vascular resistance is increased with intrarenal vasoconstriction, and CO is decreased, causing decreased RBF.
So, the present study aimed to detect the prevalence of thyroid function abnormalities in patients with chronic renal failure under regular hemodialysis.
To get this target accomplished, the present study included one hundred patients on regular HD. They were subjected to careful history taking, thorough clinical examination and laboratory investigations including virological state, renal functions and thyroid functions.
In the present study, the included patients had a mean age of 56.92 ± 15.29. They comprised 57 females and 43 males.
Regarding prevalence of HCV infection in the studied group, we found that 60 % of patients had HCV.
In our study, 40 patients (40%) of our studied group having chronic renal failure due to hypertension; 25 patients (25%) due to diabetes mellitus; 11 patients (11%) due to congenital polycystic kidney; 9 patients (9%) due to obstructive uropathy ; 9 patients (9%) due to systemic lupus erythromatosis ; 6 patients (6%) due to recurrent urinary tract infection.
In the current study, 92% of patients are having normal TSH levels while 8% are having abnormal TSH levels.
Regarding T3 levels, the present study found that 67 % of the studied patients had normal T3 while the remainder 33 % had abnormal T3. In addition, only 11 patients had abnormal T4.
In respect to the thyroid hormone status in the studied patients, we found that only one patient is hyperthyroid ’’has got low TSH level’’, 92% of our patients are in euthyroid status ’’have got normal TSH levels’’,2% are clinically hypothyroid ’’have got high TSH levels & low T4 levels’’, 5% are subclinically hypothyroid’’ have got high TSH levels with normal T4 levels &they are not complaining of hypothyrodism’’.
In our study females were found to have significantly higher T3 and TSH levels while no significant differences were found between males and females regarding T4.
In the present study, no significant associations were found between HCV infection and the thyroid hormones levels.
Regarding the correlations between thyroid hormones and the various clinical and laboratory data, we found only a significant direct correlation between TSH level and duration of hemodialysis.
In this study, patients with abnormal TSH had significantly higher frequency of abnormal T4 but not T3.