الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
This thesis is dealing with the synthesis and characterization of two series of mixed ligands complexes; the first formed from Levofloxacin as a primary ligand and 8- hydroxylqunoline as secondary ligands while the second series is formed from levofloxacin as primary ligand with 1,10- phenanthroline as secondary ligand and the metal ions: F3+, Ni2+, Cu2+ and Zr4+. The antimicrobial and antitumor activities of the synthesized complexes were also tested. The thesis consists of three main chapters.
Chapter 1: Introduction.
In which an outlook about the mixed ligands complexes with transition metal ions with different ligands was presented with a brief explanation of their biological activity, structure-relationship and spectral behavior. A literature survey for the previous studies carried out on the similar mixed ligands drugs complexes was also introduced.
Chapter 2: Experimental.
Include complete description of the apparatus and instruments used in the study. It also explains the method of preparation of the mixed ligands complexes and the different techniques used for their characterization. The methodology of antimicrobial and antitumor activities was also described.
Chapter 3: Results and discussion.
Which contain the results obtained and their discussions where it was found that:
1- Results of elemental analysis agree well with the theoretical values of the proposed formulae. The values reveal the formation of primary ligand : metal ion: secondary ligand complexes with stiochiometric ratio 1 : 1 : 1. The molar conductance values (Ʌm; ohm-1 cm2mol-1) indicate the ionic nature of the complexes with a total number of two or three ions.
2- The thermogravimetric analysis showed that the complexes thermally degraded in, more or less, three main steps. The first and second steps are due to the removal of either physically adsorbed or coordinated water molecules attached to the solid complexes in addition to some gases produced from the pre-decomposition of the complexes such as N2 or CO2. The third degradation step is due to the decomposition of the complexes leading to the formation of metal oxides as final products from which the % of metal ion was calculated.
3- Inspection of the IR spectral bands of the complexes shows that the spectra of the free ligands show strong band characteristic for the stretching vibrations of carbonyl (VC=O), hydroxyl (VOH) and VC=N groups. These bands suffer a notable shift to lower frequencies in the spectra of complex species as a result of donation of lone pairs of electrons to form the coordination bonds. The far infrared region of the spectra of the metal chelates shows three new sets of bands within the regions663–785, 557-717 and 452 - 520 cm-1 which are due to the stretching vibrations of M – O and M – N bonds, respectively. Accordingly the mode of bonding of such complexes.