الفهرس 
Pathophysiology of Parkinson’s diseaseOnly 14 pages are availabe for public view
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Abstract
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Abstract
Parkinson’s disease (PD) represents the second most common degenerative disease of the central nervous system (CNS). Due to the high level of misdiagnosis, there is strong need for a diagnostic biomarker for PD. Alpha-synuclein plays a critical role in the pathogenesis of PD. The close relation between the salivary glands and the CNS could render their secretions as a useful pool of biomarkers. Aim of the work: To investigate salivary total and oligomeric Alpha-synuclein proteins as potential biomarkers in PD patients and to correlate them with PD severity and cognitive functions. Patients: Twenty five patients with PD and fifteen age and sex matched healthy subjects, as a control group, were enrolled. Methods: A complete clinical examination and evaluation was performed using Unified Parkinson’s Disease Rating Scale (UPDRS), Modified Hoehn and Yahr staging scale (MH&S) Beck Depression Inventory (BDI), Montreal Cognitive Assessment (MoCA) and Frontal Assessment Battery (FAB), Parkinson‘s Disease-Cognitive Rating Scale (PD-CRS). Samples of saliva were analyzed by specific antiasyn and antioligomeric asyn ELISA kits. Results: There was a statistically significant difference in oligomer, total, and oligomer /total ratio of alpha synuclein level. There was a statistically significance difference in MOCA, FAB and PDCRS. There was a statistically significant positive correlation between oligomer-alpha synuclein level and disease duration and between years of education and PDCRS.