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Abstract In brief, the use of stem cells in burn wound healing appears to be very promising. The signaling pathways followed by stem cells involved in the burn wound healing along with their factors and signals constitute a very dynamic and promising research field. Stem cell-based therapy has offered a novel and powerful strategy in almost every medical specialty including burns and wound management. And have proven to have tremendous potential in enhancing wound healing and facilitating skin regeneration. Choice of suitable stem cell sources in sufficient quantity, adequate culture conditions to preserve stem cell property, appropriate matrices or scaffolds to improve cell delivery efficiency will all have a great impact on the clinical outcomes of stem cell application. In terms of the anticipated clinical practice, stem cell therapy has to be improved to the point that hospital can put safe, efficient, and reliable protocols into practice. These will eventually advance the standards of burns and wound care. Hence, the role of stem cells can be extended to decreased fibrosis in burns and improved healing with less scar formation. In short, growth factors, receptors and cytokines are the factors related to stem cell homing, differentiation and proliferation. When applied to burn wounds, they led to an improved and rapid healing process. The study results documented that the stem cells dressing application to the superficial burned area is a safe, effective, cheap and an easy to gain the healing process. The clinical results provide a solid evidence of efficacy, with no side effects reported provide a proof of safety. Stem cells dressing application provided a promising method for raoid treatment for burn that will improve the quality of life in patients with burn and possible to prevent the potential wound complications in those patients who are prone to non-healing. |