الفهرس 
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Abstract
Pregnant women with diabetes are complicated by abnormal glycemic control. The causes of the fetal and neonatal sequelae of maternal diabetes are likely multifactorial; however, many of the perinatal complications can be traced to the effect of maternal glycemic control on the fetus and can be prevented by appropriate periconceptional and prenatal care.
Mean platelet volume (MPV) is an indicator of platelet size, function, the rate of platelet production and activation which is readily measured automated hematology machines within the complete blood count (CBC) results. MPV also reflects the existence of thrombotic and inflammatory processes. Elevations of the MPV have been found in diabetes, obese patients, thrombocytopenia, hypothyroidism, congestive heart failure, and right ventricular enlargement.
Aim of this work was to evaluate the predictive value of MPV in infants of diabetic mothers (IDMs) for early precautions and treatment.
Our study is a case control study which was conducted on fifty Egyptian neonates (21 males and 29 females). Twenty-five patients of them were previously diagnosed as IDMs as a patient group (group A) and twenty-five neonates apparently healthy age and sex matched as a control group (group B). All of them subjected to full history, physical examination, blood samples were taken from umbilical cord in the first two hours of life before any feeding, medication and intravenous fluid infusion. On postnatal day 3 [48-72 hours] complete blood count [CBC] was repeated. Blood glucose level were recorded.
Our results showing that gestational age (weeks) for group A was (34, 35) and the gestational age for group B was (34, 35). Mode of delivery was comparable in-group A and group B has no statistically significant (P- value>0.05). Body Length (cm) and Apgar score at 5th minute after birth are comparable in group A and group B were have no statistically significant (P- value>0.05). Birth weight (Kg), Apgar score at 1st minute after birth, Apgar score difference and Apgar score percentage differences were statistically significantly higher than group B (p<0.05). The laboratory findings for group A and group B. The levels of MPV on 1st day (fL), MPV on 3rd day (fL), Difference in MPV (fL),PC 1st day (×109/μL), PC 3rd day (×109/μL), Mean corpuscular volume (Fl/red cell) and WBC count (×109/L) in group A were statistically significantly higher than in group B (p < 0.05) .Blood glucose levels (mg/dL) in group A were significantly lower than in group B (p<0.05). The MPV levels showed no correlation with the gestational age (weeks), body Length (cm), Apgar score at 5th minute, Hemoglobin level (gm/dL) and PC difference (%) (p>0.05), but we detected a correlation between the MPV levels and the birth weight (Kg),Apgar score at 1st minute ,blood glucose level (mg/dL) and WBC count (×109/L) (on 1st day) and on (3rd day) with (p<0.05) . ROC curve analysis, MPV on 1st day (fL) >9.5 fL had a sensitivity of 100% and a specificity of 89.29% for predicting hypoglycemia (P<0.001). ROC curve analysis, MPV on 3rd day (fL) >10 fL had a sensitivity of 100% and a specificity of 89.29% for predicting hypoglycemia (P<0.001).
It can be concluded that MPV, a simple and readily available biomarker, is significantly higher in preterm neonate’s infant of diabetic mother. This might be associated with inflammatory and oxidative process.
We recommend that further studies are needed to explain the role that mean platelet volume plays in different diseases in neonatal intensive care units