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Abstract Summary and Conclusion The present work was performed to study the effect of crocin on letrozole -induced polycystic ovarian syndrome. Forty female rats were used in this study; these animals were divided into four main groups (ten rats each). group I: control group. Received 0.5 ml saline daily by intra peritoneal injection (IP) and 0.5 ml saline by oral gavage for 21days. group II: Letrozole- induced PCOS group. Received letrozole 1mg/kg for 21 consecutive days by oral gavage. group III: Crocin-treated group. Received letrozole with the same dose as in group II then crocin 50mg/Kg once daily by intraperitoneal injection for 6weeks. group IV: standard group. Received letrozole with the same dose as in group II then clomiphene citrate 1mg/ kg once daily by oral gavage for 6weeks. At the end of the experimental period, all animals were sacrificed and blood samples were collected by cardiac puncture for analysis of: - Blood glucose level. - Blood insulin level. - Insulin resistance (I R) - Total cholesterol level. - Blood testosterone level - Blood estradiol level. - Blood FSH and LH level. 91 Summary and |