الفهرس 
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Abstract
The objective of this study was to investigate relation between
MMP-9 in blood of acne patients and disease severity and its possible use
as a biomarker of acne severity. Samples were collected from 45 patients
with mild to moderate acne vulgaris. They were selected from
Dermatology out-patient clinic in Menoufia University hospital. A group
of 20 normal controls were selected matched for age and sex. Every
patient was subjected to complete history taking, general examination,
local examination of acne vulgaris.
The results of the present study revealed the following:
, 22 males (48.89%) and 23 females (51.11%), their age ranged
from 17-25 years with a mean ± SD of 20.067 ± 1.935 and 20 control
subjects matched for age and sex, 13 males (65.00%) and 7 females
(35.00%), their age ranged from 17-25 with a mean ± SD of 20.650 ±
2.758.
The acne patients were divided into 3 groups: mild, moderate and
severe, each group included 15 patients. Regarding MMP-9 level in acne
patients, the mean ± SD was 32.896 ± 28.926 while the level of controls
was with a mean ± SD of 11.818 ± 7.580.
There was a significant difference in the level of MMP-9 between
patients and controls with a P-value of 0.002.
Using ANOVA test, MMP-9 level in the group with mild acne was
found to have a mean ± SD of 13.689 ± 3.675 while in moderate acne group, mean ± SD of 23.679 ± 7.022, and that for severe group had a
mean ± SD of 61.320 ± 34.857.
Tukey’s test showed a significant difference between mild and severe
group <0.001 also between moderate and severe <0.001. There was an
association between MMP-9 blood levels and the number of regions with
inflammatory nodules and pustules but not with scars. MMP-9 level did
not correlated with duration of illness, age or sex of the patients.
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